1. According to the study narrative and Figure 1 in the Flannigan et al. (2014) study, does the APLS UK formula under- or overestimate the weight of children younger than 1 year of age? Provide a rationale for your answer.

2. Using the values a = 3.161 and b = 0.502 with the novel formula in Figure 1 , what is the predicted weight in kilograms (kg) for a child at 9 months of age? Show your calculations.

3. Using the values a = 3.161 and b = 0.502 with the novel formula in Figure 1 , what is the predicted weight in kilograms for a child at 2 months of age? Show your calculations.

4. In Figure 2 , the formula for calculating y (weight in kg) is Weight in kg = (0.176 × Age in months) + 7.241. Identify the y intercept and the slope in this formula.

5. Using the values a = 7.241 and b = 0.176 with the novel formula in Figure 2 , what is the predicted weight in kilograms for a child 3 years of age? Show your calculations.

6. Using the values a = 7.241 and b = 0.176 with the novel formula in Figure 2 , what is the predicted weight in kilograms for a child 5 years of age? Show your calculations.

7. In Figure 3 , some of the actual mean weights represented by blue line with squares are above the dotted straight line for the novel formula, but others are below the straight line. Is this an expected ﬁnding? Provide a rationale for your answer.

8. In Figure 3 , the novel formula is (weight in kilograms = (0.331 × Age in months) − 6.868. What is the predicted weight in kilograms for a child 10 years old? Show your calculations.

9. Was the sample size of this study adequate for conducting simple linear regression? Provide a rationale for your answer.

10. Describe one potential clinical advantage and one potential clinical problem with using the three novel formulas presented in Figures 1, 2, and 3 in a PICU setting.

__Exercise 19__

1. According to the relevant study results section of the Darling-Fisher et al. (2014) study, what categories are reported to be statistically signiﬁcant?

2. What level of measurement is appropriate for calculating the χ 2 statistic? Give two examples from Table 2 of demographic variables measured at the level appropriate for χ 2 .

3. What is the χ 2 for U.S. practice region? Is the χ 2 value statistically signiﬁcant? Provide a rationale for your answer.

4. What is the df for provider type? Provide a rationale for why the df for provider type presented in Table 2 is correct.

5. Is there a statistically signiﬁcant difference for practice setting between the Rapid Assessment for Adolescent Preventive Services (RAAPS) users and nonusers? Provide a rationale for your answer.

6. State the null hypothesis for provider age in years for RAAPS users and RAAPS nonusers.

7. Should the null hypothesis for provider age in years developed for Question 6 be accepted or rejected? Provide a rationale for your answer.

8. Describe at least one clinical advantage and one clinical challenge of using RAAPS as described by Darling-Fisher et al. (2014) .

9. How many null hypotheses are rejected in the Darling-Fisher et al. (2014) study for the results presented in Table 2 ? Provide a rationale for your answer.

10. A statistically signiﬁcant difference is present between RAAPS users and RAAPS nonusers for U.S. practice region, χ 2 = 29.68. Does the χ 2 result provide the location of the difference? Provide a rationale for your answer.